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For GIPR antagonist activity, HEK293T cells stably expressing human GIPR were used to measure peptide or peptideantibody conjugate-induced cAMP production in a homogenous time-resolved fluorescence assay (Cisbio, cat

The chaperone function of Tsa1 prevents the accumulation of misfolded ribosomal proteins under reductive stress, which occurs when Tsa1 is present in the cytoplasm (Dauplais et al., 2021

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The mechanism involves direct action on pancreatic alpha-cells and potentially indirect effects through paracrine signaling within the islet microenvironment