Forbes D, Withers G
However, its effectiveness and safety in comparison to semaglutide, another type 2 diabetes medication, have not been studied
Funding LS is funded by a Rosetrees Trust and Pears Foundation Advancement Fellowship, SC is funded by a BBSRC LIDo-DTP PhD studentship (BB/T008709/1) and UD is funded by an MRC DTP PhD studentship (MR/W006774/1)
However, neither the innate nor the adaptive immune response is affected by the DPP-4 inhibitors being used clinically (128), and reassuringly, there is no evidence for any increased risk of infections in the pooled safety analyses (119123) or in the CV safety outcome trials (125127), in line with the view that the catalytic activity of DPP-4 is not necessary for the co-stimulatory role of CD26 in T-cell activation
Hussain T, Tan B, Murtaza G, Liu G, Rahu N, Kalhoro MS et al (2020) Flavonoids and type 2 diabetes: evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy