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Nature 533 , 481486 (2016)

This approach ensures that the nanomaterial will be activated primarily in the vicinity of pathogenic bacteria, which thrive in such environments and will remain inactive in the more neutral pH of healthy tissues, pH-responsive NPs are commonly made using materials like chitosan, which undergoes protonation in acidic conditions, leading to a release of encapsulated drugs or antimicrobial agents at infection sites

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In order to distinguish the exact cellular site where DDX3X and pUs3 interact, we fractionated our cells into cytoplasm, nuclear matrix and nuclear membranes prior to co-IP