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At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

Effects of oral collagen for skin anti-aging: a systematic review and meta-analysis

Pitsikas, 2024)

What the research says Recent results from a late-stage clinical trial called REDEFINE 1, which included 3,417 people with overweight or obesity (without type 2 diabetes), showed that CagriSema led to almost 23% weight loss, surpassing cagrilintide and semaglutide alone

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