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Additionally, rapid weight loss associated with GLP-1 therapy triggers metabolic shifts that may alter urine pH and glucose levels, both of which influence bladder bacterial colonization

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Therefore, despite being only a partial effector of carcinogenesis, CBS belongs to a panel of intervening players, including NF-B, KRAS, p53 and Wnt components, that contribute to metabolic rewiring and increased proliferative and invasive potential