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The reason for this is that the initial wave of drug-induced hepatocellular destruction is followed by a robust innate immune response, in which invading inflammatory cells release toxic oxidants and cause a second wave of destruction

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Hospitalized patients typically receive these antibiotics for 5-8 days, potentially causing long-lasting microbial alterations

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(2) The remaining hepatocytes are not regenerated along the original scaffold, but form irregular nodular clusters of hepatocytes (regenerated nodules) (Iredale, 2007)