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Variants were filtered, as previously described ( In Silico Analysis Wild-type (WT) and TRIP13 variants were assessed using the SWISS-MODEL software ( based on the 6f0x.1.C.pdb template

Oxygen can be added to either end of the pentadiene system with high stereospecificity, and in the case of linoleic and linolenic acids, this leads to either the 9 S - or 13 S -hydroperoxy derivatives or both depending on the isoform of the enzyme

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