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Supplements are most useful when theres a gap, such as chronic illness, high oxidative load, gut issues that impair nutrient absorption, or aging-related decline in glutathione synthesis

Yes, untreated vitamin B12 deficiency can cause irreversible neurological damage, particularly affecting peripheral nerves and the spinal cord

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It seems however, (at least based on a limited number of studies) that degeneration, loss of function, dysregulated metabolism, impaired second messenger signalling and death of astrocytes are predominant pathophysiological manifestations

Oral contraceptive use is associated with smaller hypothalamic and pituitary gland volumes in healthy women: A structural MRI study