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Unlike Crohns disease, ulcerative colitis usually does not affect the full thickness of the intestine and rarely affects the small intestine

[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Williams L.M., Berthon B.S., Stoodley I.L., Williams E.J., Wood L.G

These studies indicated that in response to oxidative stress, there is not only an increase in expression of both PA28 and PA28 over the subsequent 24 h, but also enhanced capacity of the 20S proteasome to selectively remove oxidative damaged proteins (Pickering and Davies, 2012b)

This is your adjustment period for both medications, and getting baseline thyroid labs before this phase is essential