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In rats, on the other hand, lesions of the AP or administration of exendin (939) into the 4th ventricle blocked the food intake inhibition by GLP-1 infused into the hepatic portal vein [261], suggesting that high concentrations of circulating GLP-1 act on the hindbrain to reduce food intake

This enables the body to use less muscle mass to maintain blood sugar and insulin sensitivity in the cells

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Additionally, no abnormalities in diet and behavioral activities were observed in nude mice during the experiment, regardless of whether they were treated with or without Formononetin