Stimulants, including amphetamine, methamphetamine, cocaine, and ephedrine exceeding regulatory thresholds, are banned in competition due to their alertness-promoting and fatigue-masking properties
Oral L-carnitine supplementation at 1,000-2,000 mg daily can achieve similar blood levels, though oral bioavailability is lower (15-25%) compared to injectable forms
For IDH1 inhibitor and carnitine synthesis inhibitor studies: cells pre-treated with the IDH1 inhibitor GSK864 (Ovcar8 cells: 10.565M, FT282 cells: 12.24M) or mildronate (145M for both cell lines), and various metabolites such as KG (330M), L-carnitine (1mM), O-Acetyl-Carnitine (1mM), Propionyl-L-carnitine (1mM), Butyryl-L-carnitine (1mM), Citrate (333nM), Succinate (1mM), nacetyl-l-cysteine (NAC, 0.5M) for a period of 5 days, replacing drugs and metabolites every other day
It is worth noting that this Thorne product carries the NSF Contents Certified certification whereas the Momentous product is NSF Certified for Sport
Nazary-vannani A, Ghaedi E, Mousavi SM, Teymouri A, Rahmani J, Varkaneh HK