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The risks of opioid use while on Suboxone is more related to chasing the high that Suboxone is blocking, taking the same opioid dosing after even brief periods of sobriety or in combination with other depressant drugs like benzodiazepines or alcohol

Given Glus critical role in synaptic plasticity, it is possible that immune dysfunction triggered by gluten consumption could lead to prolonged activation of post-synaptic Glu receptors, contributing to increased neuronal excitability (Pennisi et al

(2023) 34:ar85