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1, 2 Previous studies have reported that decreased expression of UCP-1 caused by various conditions such as fasting, deletion of the UCP-1 gene, and obesity (eg, ob/ob and db/db mice) induces a low body temperature resulting from the impaired thermogenesis in BAT

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Insulin receptor, insulin-like growth factor-1 receptor and insulin resistance signalling As a brief review of insulin signalling and its resistance molecular basis: insulin and IGF-1 receptors (IR and IGF-1R) are tyrosine kinases

An automated 14:10 hour light-dark cycle, incorporating 30-minute brightening and dimming periods, was maintained [2]