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Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats

In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

Hankosky ER, Chinthammit C, Meeks A, et al

So that makes a lot of sense in terms of diabetes control and diabetes management

Gruarin P, Primo L, Ferrandi C, Bussolino F, Tandon NN, Arese P, Ulliers D, Alessio M (2001) Cytoadherence of Plasmodium falciparum-infected erythrocytes is mediated by a redox-dependent conformational fraction of CD36