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glyoxalases, which use GSH to detoxify reactive dicarbonyl species including methylglyoxal and glyoxal

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*In the STEP 1 trial, participants received semaglutide 2.4 mg once weekly via subcutaneous injection, the FDA-approved formulation later marketed under the brand name Wegovy for chronic weight management in adults with obesity or overweight and at least one weight-related condition

(53) documented a notable decrease in Prevotella abundance in postmenopausal osteoporosis patients (PMOP), demonstrating protective effects on bone mass, likely through modulation of intestinal permeability and inhibition of osteoclast activity via suppression of osteoclastogenic cytokines