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Semaglutide's safety profile is well-established from extensive clinical trial experience, though patients with sleep apnea warrant specific considerations

If clinical suspicion exists based on history or examination findings, appropriate evaluationpotentially including thyroid ultrasound, serum calcitonin, or genetic testing for RET mutationsshould be completed before starting therapy

Calorie reduction: By suppressing appetite and cravings including emotional eating patients naturally consume fewer calories without feeling deprived

To put that into perspective, someone who started the trial at 300 pounds could theoretically lose about 60 pounds on tirzepatide versus roughly 41 pounds on semaglutide over about a year and four months

There is increasing evidence of therapeutic efficacy regarding mitochondrial peptides in T1D 7,10