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This adaptation, while energy-conserving, manifests as increased cold sensitivity

Side effects, including dyskinesias, on-off syndromes, and psychotic disorders, can emerge after long-term utilization of dopaminergic agonists [12]

What differs between these assays is the sensors solubility

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In human pulmonary fibroblast cultures, Epithalon treatment induced telomerase activity in cells that had ceased expressing the enzyme, resulting in telomere elongation and an extension of replicative lifespan beyond the Hayflick limit [1]