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Once the adipose tissue expandability exceeded limit under overnutrition, excess lipids and toxic lipid metabolites (FFA, diacylglycerol, ceramide) accumulated in non-adipose tissues, thus leading to lipid-induced toxicity (lipotoxicity) and developed IR in liver and muscle

The company also says the plaintiffs expert witnesses are not qualified

Novo Nordisk noted in a news release that it expects an estimated direct, negative low single-digit impact on global sales growth in 2026