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A meta-analysis of 62 case-control and two cohort studies revealed that while the T/T variant reduces CRC risk by 12% compared to both C/T and C/C genotypes, the risk was decreased by 30% with high (348-1,583 g/day) versus low total folate intakes (264-450 g/day), irrespective of the genotype (137)

Its a long and convoluted story that involves several agencies and I will do my best to explain the process although I will have to confine my report to the situation in the UK

Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species