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Should one develop, consult a physician

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It is plausible that the lack of ergogenic effects could be attributed to the trained participant cohort in the cycling studies (VO 2peak range = 56.3 58.1 ml.kg 1 .min 1 ), such that a recent point-counterpoint debate suggests due to an elevated NO at baseline compared to their untrained counterparts this could blunt the ergogenic effect (Hultstrm et al

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Air pollutants (PM2.5, NO), heavy metals (lead, cadmium), and microplastics have each been associated with excessive ROS production, that leads to lipid peroxidation, mitochondrial dysfunction, and sperm DNA fragmentation (22)