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Early Phase 2 data published in the New England Journal of Medicine in 2023 showed considerable promise, but retatrutide has not yet received approval from the MHRA or EMA

In in vitro assays, retatrutide has been observed to act as a balanced agonist at GLP-1R and GCGR, while demonstrating enhanced potency at the GIPR (approximately 8.9 times more potent than endogenous GIP at that receptor)

Nauck MA, Kemmeries G, Holst JJ, Meier JJ (2011) Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

Figure 2 3.1 Study characteristics and quality The nine publications evaluated included six clinical studies, two case series, and one survey

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