Indications, side effects, and access for the approved option Across the GLP-1 class, FDA-approved uses include type 2 diabetes, chronic weight management for Wegovy, Saxenda, and Zepbound, cardiovascular risk reduction in type 2 diabetes for several products, and obstructive sleep apnea for Zepbound as of 2024
Their primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which generally reduces the risk of hypoglycaemia (though this risk increases when combined with insulin or sulfonylureas) Suppressing glucagon release from pancreatic alpha cells, thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces postprandial glucose excursions Acting on appetite centres in the hypothalamus to reduce hunger and food intake These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight reduction in those prescribed these medications for obesity management
Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Learn more about Panthenol Collagen is a big structural protein that your body uses to keep skin firm and bouncy
Many clients choose this option for both health and cosmetic results, often seeing improved wellness and radiant skin
