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The volume of the uncalcified pineal gland correlates to the peak amount of melatonin produced at night.[ref][ref] Extra-pineal melatonin: Researchers have found out more recently that melatonin production occurs outside of the pineal gland as well

Post-infection gut dysbiosis drives systemic inflammation, leaky gut, and immune dysregulation all of which amplify fatigue, cognitive impairment, and mood instability.3 BPC-157 has been shown in multiple animal studies to: Accelerate healing of the intestinal epithelium4 Reduce gut inflammation and restore tight junction integrity5 Modulate the vagus nerve, which connects gut function to brain and immune signaling6 For long COVID patients dealing with GI symptoms, food intolerances, or fatigue that tracks with gut dysfunction, this mechanism is directly relevant