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Even at low doses, GLP-1 medications arent appropriate for everyone

For instance, tirzepatide, a dual GLP-1/GIP receptor agonist, has shown even more pronounced effects on weight reduction than GLP1-RAs alone, with clinical trials reporting weight loss exceeding 15% from baseline

Patients should be monitored closely for side effects and determine long-term goals on this medication class. Ni said that weight loss medications are meant to be a short-term solution while lifestyle habits produce long-term results

Relying solely on the drug without addressing nutrition or activity levels often leads to muscle loss rather than just fat loss, or weight regain if the medication is stopped

Primary MCAS : This results from a genetic alteration in the mast cells, resulting in a clonal population of mast cells (genetically identical cells)