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For example, in 2021, a three-month double-blind trial involving 85 people with dementia demonstrated a "clear correlation" between high spermidine intake (3.3mg per day) and improved performance on the Mini-Mental State Examination.15 Another study, published the following year, points to a potential mechanism of action: that spermidine's role as an autophagy activator may help counter Alzheimer's dementiarelated neuroinflammation and degrade amyloid beta, a brain protein associated with Alzheimer's disease.16 Also worth noting is a 12-month trial with 100 subjects that demonstrated "no significant changes" in memory performance with 0.9mg of spermidine per day

This helps counter toxins or pathological conditions and supports its protective effects across organ systems

veneers enhance healthy ones

PSAP, Prosaposin

This accumulation of misfolded proteins initiates the UPR to restore normal function