In such enzyme-triggered release systems, the nanomaterials are coated or functionalized with substrates that can be selectively cleaved by bacterial enzymes
425,426 In the heart tissue of conditional frataxin knockout mice, increased mRNA levels of MFRN2, SEC15L1, and TFR1 and decreased mRNA levels of FPN1 indicate an activated response to cytoplasmic iron deficiency and increased mitochondrial iron input
The gut microbiota-immune-brain axis: therapeutic implications
1,2,6 Because nonantimicrobial sulfonamides lack an arylamine group, they do not produce similar metabolites, which is the reason they do not cross-react in patients who have had nonIgE-mediated reactions to antimicrobial sulfonamides
Brain Sciences (2021) This study by an independent research group (outside the original Washington State University team) demonstrated that Dihexa rescues cognitive impairment in an Alzheimer's disease mouse model (APP/PS1 transgenic mice)