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Clin Pharmacokinet 2003;42:941-67

Tinnitus, commonly described as a persistent ringing or buzzing in the ears without an external source, arises from intricate cellular dysfunction within the auditory pathway

Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway

[1] [8] When used with insulin or sulfonylureas, there is an increased risk of hypoglycaemia, which may require dose adjustments of these medications

Phenylbutazone was originally developed for chronic pain for conditions such as arthritis but has since been restricted to treating ankylosing spondylitis due to induction of rare but severe blood disorders, including anemia and leukopenia 86