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A positive result strongly supports the diagnosis and the need for lifelong B12 replacement
Alternatively, if the elevated anion gap persists despite cessation of acetaminophen and administration of N-acetylcysteine, pyroglutamic acidosis is unlikely, and an alternative diagnosis should be sought
Lister R, Ecker JR (2009)
When it becomes intense and prolonged, however, it takes a huge toll I recommend getting outside and going on a walk, practicing a few minutes of deliberate breathwork, meditating, using technology, or any of these stress biohacks to quickly get back on track