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This condition happens when there is excess melanin, which is the pigment that is responsible for skin color

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Furthermore, we did not use operationalized criteria (for example, Diagnostic and Statistical Manual 5th edition) to define the populations of interest because these would not be applicable across animal and human studies, but instead relied on the definitions provided by the individual articles

Others have their own blood-thinning or clot-promoting effects, which, correspondingly, may increase or reduce the effectiveness of warfarin