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Defects in the AR gene can be caused by four types of mutations: (i) Single point mutations resulting in substitutions or premature stop codons, (ii) nucleotide insertions and deletions resulting in frameshifts, (iii) complete or partial deletion of the gene, or (iv) intronic mutations that affect AR RNA splicing 103

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Formation of ROS via photo-oxidation affects the rods more severely since these cells detect dim light to provide night vision and are more vulnerable to damage induced by daylight 23