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As it is a water-soluble vitamin, excess Vitamin B12 is simply eliminated via the urine

LeRoy, G., Hahn, J

While many patients report ISP, its intensity often decreases with repeated administrations, leading to increased tolerance

Transparent communication with your healthcare team about thirst, urination patterns, and any symptoms like fatigue or swelling allows early intervention and dose adjustment if needed

Ghrelin may even contribute to genetic predispositions for sweet taste preference as in a Swedish population cohort, specific haplotypes for the pro-ghrelin gene are associated with an elevated consumption of sucrose, especially in men [72]