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Because they are naturally occurring sequences in the human body, they are generally well-tolerated with minimal documented toxicity

March 2, 2021

doi:10.3390/antiox8040082 15

The mechanisms through which these phytochemicals exert their effects include the inhibition of the MAPK/NF-B signaling pathway (notably by (2 S ,7S)- O -(2-methylbutanoyl)-columbianetin, tussilagone, platycodin D, skullcapflavone II, and diosmetin), the inhibition of IB and COX-2 signaling pathways (as seen with resveratrol and -glucan), the suppression of the STAT6/SOCS1 and GATA3/T-bet signaling pathways (mediated by morin), and the inhibition of the TLR4/MyD88/NF-B signaling pathway (as demonstrated by apigenin)

Research dosages range from 10 mcg/kg to 10 mg/kg depending on the study protocol and target tissue being investigated