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The system Xc- consists of a light chain subunit solute carrier family 7 member 11 (SLC7A11) and a heavy chain subunit solute carrier family 3 member 2 (SLC3A2) (Sato et al., 1999), linked by a disulfide bond, which transport extracellular cystine into cells in exchange for intracellular glutamate (Parker et al., 2021)