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By directing the delivery of the NMDA receptor antagonist MK-801 via GLP-1 pathways, the researchers were able to influence neuroplasticity in the hypothalamus and brainstem

NEJM 2022)

If GLP-1 agonists show superior neuroprotective benefits, this could challenge the traditional treatment paradigm and support initiating therapy with GLP-1 agonists in selected patients. GLP-1 agonists have demonstrated mechanisms that include reducing neuroinflammation, enhancing cerebral glucose metabolism, and improving synaptic plasticity, Wu added

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