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Similarly, trials of semaglutide have shown substantial reductions in waist circumferencea clinical surrogate for visceral adiposityalongside improvements in cardiometabolic markers including hemoglobin A1c, blood pressure, and lipid profiles
Within that LBM reduction, liver mass dropped approximately 20% while skeletal muscle showed only modest, often non-significant changes
In Drosophila melanogaster , the peptide reduced mitochondrial and cytosolic ROS levels, along with lipid peroxidation markers such as Schiff bases and hydroperoxides
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