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A systematic review and meta-analysis published in eClinicalMedicine found that discontinuing GLP-1 receptor agonist treatment led to an average weight regain of 5.63 kg and 5.81% of body weight across all patients studied

Alternative therapies with established safety profiles should be considered

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Moreover, reductions in alcohol/drug responses (hyperactivity, dopamine release, and CPP), which are not influenced by ingestion, are observed

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