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Methylation levels of SFRP1 , SFRP2 , SDC2 , and PRIMA1 were determined using a MethyLight assay after cfDNA isolation and bisulfite conversion of samples ( SOX21 gene promoter methylation, serving as a fecal-based noninvasive biomarker for early diagnosis of colorectal cancer (Moradi et al., 2021)

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Based on these results and on the numerous functions of GSH in cellular homeostasis and defense [35], a loss of GSH may represent a critical factor in the aging process [36]

This helps regulate essential hormones such as thyroid, cortisol, and insulin, all of which are needed for effective metabolism and weight management

For this reason the terms HDN and NNJ cannot be regarded as interchangeable, at least in the context of G6PD deficiency