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confirmed that treatment of AR mice with glycyrrhizin reduced IgE, IL-4, IL-5, IL-6, NO, TNF-, and NOS, and increased IgA, IgG, IL-2, and IL-12 levels in the blood as well as in nasal mucosa, reduced substance P, and raised acetylcholinesterase (AchE) activity (Li and Zhou, 2012)

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Power calculations suggest that previous studies would have had limited power to detect an effect size similar to that identified in our study (Supplementary Table 23), and also differed in terms of drug type, disease cohort and analytical choices

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