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J Diabetes Investig 11:15511563 Ott C, Jumar A, Striepe K, Friedrich S, Karg MV, Bramlage P, Schmieder RE (2017) A randomised study of the impact of the SGLT2 inhibitor dapagliflozin on microvascular and macrovascular circulation

Some providers may consider brief dose reduction followed by return to full dose as a receptor resensitization strategy, though evidence for this approach remains limited

In a Phase 2 trial, adults with obesity lost about 24% of their body weight after 48 weeks, the largest drop reported for this class so far

J Mol Biol 370(2):231245 Adhami VM, Aziz MH, Mukhtar H, Ahmad N (2003) Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes

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