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The standard titration schedule for Ozempic begins at 0.25 mg once weekly for at least four weeks, increasing to 0.5 mg, with further increases to 1 mg or 2 mg if required for glycaemic control, maintaining each dose for at least 4 weeks before increasing

2012 Jul 31;2(3):203a10

Cell 108, 271282

Preclinical studies show that activation of the GLP-1R by GLP-1 or GLP-1RAs weakens the ability of alcohol to activate the mesolimbic dopamine system, as well as reduces alcohol consumption and operant self-induction