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For detailed information about this topic, read our comparison of Ozempic vs compounded semaglutide

They plateau on semaglutide and wonder if the "equivalent" tirzepatide dose would work better, without realizing no true equivalence exists

The ICER report shows that GLP-1s, at the cost that they are currently being sold, provide tremendous value to society, he said

Protocol 1: moderate weight loss (10-15% body weight) Goal: Steady, sustainable weight loss with minimal side effects Tirzepatide approach: Standard escalation to 5-7.5 mg Hold at the dose where you achieve consistent weekly loss of 0.5-1% body weight Expected timeline: 24-36 weeks to target Likely maintenance dose: 5-7.5 mg Retatrutide approach: Standard escalation to 4 mg 4 mg delivered 12.9% weight loss at 24 weeks in trials Hold at 4 mg if achieving target rate Expected timeline: 20-30 weeks to target For moderate goals, both compounds work well at their lower dose ranges

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