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Anyone with existing health conditions, people taking prescription medications, and those who are pregnant or breastfeeding should consult a licensed healthcare professional before starting use

MOTS-c Research Protocols & Administration Dosing in Published Research Research investigations have employed MOTS-c doses that vary significantly depending on species, experimental model, and research objectives: Mouse studies: 5-15 mg/kg most common (range: 5-50 mg/kg reported) Rat studies: 10-50 mg/kg used in inflammatory pain models Human endogenous levels: Approximately 2-20 ng/mL plasma (wide variation reported) CB4211 analog (human Phase 1): 15-250 mg/kg tested for safety in mice

Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer

Delaloge, S., Khan, S

Lower concentrations mean larger volumes (slightly less convenient) but are more forgiving of small measurement variations