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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial

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Its detected by: - Increased serum creatinine (always compare with baseline creatinine!) - Decreased urine output Causes of AKI Pre-renal (most common): Inadequate perfusion - Kidneys are intact but starved of blood Causes: dehydration, blood loss, sepsis, heart failure Intrarenal: Direct damage to kidney tissue - can occur after prolonged pre-renal AKI Causes: Nephrotoxic medications (e.g