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In all models, the following fixed covariates were entered: assigned treatment (investigational product or placebo), baseline measurement of the outcome of interest, visit (day 14 1 day or day 28 1 day), visit in interaction with treatment, period (period 1 or period 2), sex and, for MIDT outcomes, incentive level

10.1016/j.biopha.2021.111540 3 AlthunibatO

These include lack of awareness of health care professionals about prompt diagnosis and adequate management of hyperammonemia, strained communication between physicians at primary, secondary, and tertiary hospitals, and lack of knowledge and availability of the diagnostic tools and medications required in the acute management of hyperammonemia