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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)

Results for the Extension Phases of Studies 1 and 2 are presented in Tables 4 and 5

Histologically, the lesion is composed of spindle cells in a collagenous myxoid stroma and the cells showed S-100 protein positive

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