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This suggests that glutathionylation of one of these cysteine residues may be an intermediate toward the formation of the intermolecular disulfide in isoforms possessing both cysteines

This makes sense because the liver is the primary organ responsible for detoxification

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Thus, GLS2 can promote glutathione synthesis, improving antioxidant responses [206], being targeted for activation against tumors that thrive on ROS-mediated DNA damage and chromatin instability

Other types of cancer In a small, placebo-controlled intervention study in 50 patients with cancer (42 with liver cancer, seven with pancreatic cancer, and one with colon cancer), supplementation with 500 mg/day of aged garlic extract for six months failed to prevent quality of life deterioration caused by disease progression and chemotherapy-associated adverse effects (133)