[3] That said, individual response varies, and factors like side effects tolerance, dosing preference, and cost should guide your choice
doi: 10.3389/fnut.2020.00143 Received 26 June 2020 Accepted 21 July 2020 Published 02 September 2020 Volume 7 - 2020 Edited by Christophe Matthys, KU Leuven, Belgium Reviewed by Alan Diamond, University of Illinois at Chicago, United States
Should be taken with the first bite of breakfast, lunch, and dinner the hypoglycemic goal in diabetics typically cannot be met with these drugs alone Side Effects: bloating, gas, abdominal discomfort, diarrhea these side effects develop due to the fermenting of undigested carbohydrate in the colon to fatty acids, with resultant release of gas side effects can diminish over time due to upregulation of -glucosidase in the distal small intestine, which increases glucose absorption & reduces the amount of carbohydrate entering the colon Major drug interactions: ) MAO inhibitors Notes: -glucosidase inhibitors are infrequently prescribed in the US because of their prominent GI side effects & limited ability to lower glucose levels -glucosidases are a family of enzymes with different carbohydrate specificities, and include sucrase, maltase, glucoamylase & dextranase References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)
Compounded versions are available in some clinical contexts, but compounding access has been evolving rapidly and the right path depends on your situation
F.MarkopoulouK.et al
