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It appears that each melanocyte is in contact with about 35 neighbouring keratinocytes in the basal and suprabasal cell layers of the epithelium, each forming a melanocyte-keratinocyte unit [4, 6, 7]

Importantly, this metformin-mediated radiosensitisation was superior to that of 5-FU, which is the current standard of care

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Upper arm injections should be administered by a caregiver

In many cases, the optic nerve damage is permanent because nerve tissue has limited ability to regenerate after ischemic injury