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Not everyone needs to escalate to 1.7mg or 2.4mg

It addresses the pitfalls above through two core strategies: 1) a highly personalized low and slow titration protocol aimed at maximizing tolerability and finding the right dose for each individual, in combination with 2) deep lifestyle integration using behavioral science focused on ensuring patients build healthy habits alongside the medication

Completion and maintenance Protocol conclusion: After planned duration (8-16 weeks typically), discontinue daily injections

Keep your back neutral

Although the SELECT trial differs from the trials reviewed, most significantly in the recruitment of a population without diabetes (and hence potentially at lower baseline risk), it is encouraging that our calculated NNT 3P-MACE falls within the ranges reported, contributing to the face-validity of our analysis