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On the other hand, GSH and 2-mercaptoethanol displayed similar potency, needing thiol:AX ratios above 4:1 to obtain a complete abolition of antibiotic effects ( Figures 6B, C )

Furthermore, in a BK5.IGF-1 mouse model of breast cancer, elevated levels of IGF-1 expression activated the COX-2/PGE2/EP3 signaling pathway, accompanied by increased VEGF expression and tumor angiogenesis (110)